論文

Matsukawa, T., Sudo, A., Kakumoto, T., Hao, A., Chang, H., Mano, T., Ishiura, Hl, Mitsui, J., Hayashi, T., Morishita, S., Tsuji, S., Toda, T. In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy. Hum Genome Var 12, 5,2025. DOI:10.1038/s41439-025-00309-z

Nakajima, K, Ishiwata, M., Kato, T. Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain. Scientific Reports 15, 5616, 2025. DOI:10.1038/s41598-025-88514-2

Nakamura, T., Yoshihara, T., Tanegashima, C., Kadota, M., Kobayashi, Y., Honda, K., Ishiwata, M., Ueda, J., Hara, T., Nakanishi, M., Takumi, T., Itohara, S., Kuraku, S., Asano, M., Kasahara, T., Nakajima, K., Tsuboi, T., Takata, A., Kato, T. Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Molecular Psychiatry 29, 2888–2904,2024. DOI:10.1038/s41380-024-02479-8

Sato, H., Kasuga, K., Isoo, N., Hayashi, T., Ikeuchi, T., Hori, Y., Tomita, T.Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience Research, 193:63-70, 2023. DOI:10.1016/j.neures.2023.03.002

Nishikawa N, Murata M, Hatano T, Mukai Y, Saitoh Y, Sakamoto T, Hanakawa T, Kamei Y, Tachimori H, Hatano K, Matsuda H, Taruno Y, Sawamoto N, Kajiyama Y, Ikenaka K, Kawabata K, Nakamura T, Iwaki H, Kadotani H, Sumi Y, Inoue Y, Hayashi T, Ikeuchi T, Shimo Y, Mochizuki H, Watanabe H, Hattori N, Takahashi Y, Takahashi R, the Japan Parkinson's Progression Markers Initiative (J-PPMI) study group, Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study, Parkinsonism and Related Disorders, 103:129-135, 2022. doi:10.1016/j.parkreldis.2022.08.011.

Kameda, H., Murabe N., Mizukami H., Ozawa K., Hayashi T., Sakurai M. Parcellation of the murine cortical hindlimb area is demonstrated by its subcortical connectivity and cytoarchitecture. Journal of Comparative Neurology, 530:1950-1965, 2022. Doi:10.1002/cne.25313

Kurihara, M., Sugiyama, Y., Sato, K., Tanaka, M., Mano, T., Ishiura, H., Kubota, A., Hayashi, T., Iwata, A., Shimizu, J., Tsuji, S., Toda, T. Diagnostic values of venous peak lactate, lactate-to-pyruvate ratio, and fold increase in lactate from baseline in aerobic exercise tests in patients with mitochondrial diseases. Internal Medicine, Article ID 8629-21, 2021. DOI:10.2169/internalmedicine.8629-21

Ohno, T., Fukuda, S., Murabe, N., Niido, M., Sakurai, M. Temporal Course of Transient Direct Corticomotoneuronal Connections during Development in Rodents. Neuroscience,478:89-99, 2021. DOI:10.1016/j.neuroscience.2021.09.006

Fukuda, S., Murabe, N., Mizuta, H., Yamamoto, T., Nagai, T. Bio-electrical signal associated with sweet taste transduction in humans is a hyperpolarizing potential on the lingual epithelium. Chemical Senses, 2021;46:bjab040, DOI:10.1093/chemse/bjab040

Kikuchi, JK., Nagashima, Y., Mano, T., Ishiura, H., Hayashi, T., Shimizu, J., Matsukawa, T., Ichikawa, Y., Takahashi, Y., Karino, S., Kanbayashi, T., Kira, J., Goto, J., Tsuji, S. Cerebellar ataxia as a common clinical presentation associated with DNMT1 p.Y511H and a review of the literature. Journal of Molecular Neuroscience, 71(9):1796-1801, 2021. DOI:10.1007/s12031-020-01784-5

Murabe N., Okumura E., Chiba K., Hosoda E., Ikegami S., Kishimoto T. The Starfish Asterina pectinifera: Collection and Maintenance of Adults and Rearing and Metamorphosis of Larvae. In: Carroll D.J., Stricker S.A. (eds) Developmental Biology of the Sea Urchin and Other Marine Invertebrates. Methods in Molecular Biology, vol 2219. Humana, New York, NY, 2021. DOI:10.1007/978-1-0716-0974-3_3

Mimura, T., Mizota, A., Hayashi, T., Nishimura, S. In situ Observations of Porcine Ocular Surface Cells with Handheld 2K-pixel Microscope. The Open Ophthalmology Journal, 14(1), 66–69, 2020. DOI:10.2174/1874364102014010066

Kurihara, M., Orimo, K., Mano, T., Miyano, R., Kamisawa Sato, A., Sato, K., Ihara, R., Hayashi, T., Toda, T. Gait improvement after levofloxacin administration in a progressive supranuclear palsy patient. Clinical Parkinsonism & Related Disorders, 3:100080 2020. DOI: 10.1016/j.prdoa.2020.100080

Fukuda, S., Maeda, H., Sakurai, M. Reevaluation of motoneuron morphology: diversity and regularity among motoneurons innervating different arm muscles along a proximal–distal axis. Scientific Reports 10, 13089, 2020. doi:10.1038/s41598-020-69662-z

Yoshida, M., Hayashi, T., Fujii, K., Ishiura, H., Tsuji, S., Sakurai, Y. Selective impairment of On-reading (Chinese-style pronunciation) in alexia with agraphia for kanji due to subcortical hemorrhage in the left posterior middle temporal gyrus, Neurocase, 26(4):220-226, 2020. doi:10.1080/13554794.2020.1788608

Matsukawa, T., Yamamoto, T., Honda, A., Toya, T., Ishiura, H., Mitsui, J., Tanaka, M., Hao, A., Shinohara, A., Ogura, M., Kataoka, K., Seo, S., Kumano, K., Hosoi, M., Narukawa, N., Yasunaga, A., Maki, H., Ichikawa, M., Nannya, Y., Imai, Y., Takahashi, T., Takahashi, Y., Nagasako, Y., Yasaka, K., Koshi Mano K., Kawabe Matsukawa, M., Miyagawa, T., Hamada, M., Sakuishi, K., Hayashi, T., Iwata, A., Terao, Y., Shimizu, J., Goto, J., Mori, M., Kunimatsu, A., Aoki, S., Hayashi, S., Nakamura, F., Arai, S., Monma, K., Ogata, K., Yoshida, T., Abe, O., Inazawa, J., Toda, T., Kurokawa, M., Tsuji, S. Clinical efficacy of haematopoietic stem cell transplantation for adult adrenoleukodystrophy. Brain Communications, 2(1) fcz048, Jan 2020. doi:10.1093/braincomms/fcz048

Kurihara, M., Ishiura, H., Bannai, T., Mitsui, J., Yoshimura, J., Morishita, S., Hayashi, T., Shimizu, J., Toda, T., Tsuji, S. Novel de novo KIF1A mutation in a patient with autism, hyperactivity, epilepsy, sensory disturbance, and spastic paraplegia. Internal Medicine, Dec 2019. doi:10.2169/internalmedicine.3661-19

Kameda, H., Murabe, N., Odagaki, K., Mizukami, H., Ozawa, K., Sakurai, M. Differential innervation within a transverse plane of spinal gray matter by sensorimotor cortices, with special reference to the somatosensory cortices. Journal of Comparative Neurology, 527(8)1401-1415, 2019. doi:10.1002/cne.24626

Odagaki, K., Kameda, H., Hayashi, T., Sakurai, M. Mediolateral and dorsoventral projection patterns of cutaneous afferents within transverse planes of the mouse spinal dorsal horn. Journal of Comparative Neurology, 527(5)972-984, 2019. doi:10.1002/cne.24593

Watanabe, T., Anno, M., Matsubayashi, Y., Nagasako, Y., Sakuishi, K., Fujimoto, Y., Tachibana, N., Taniguchi, Y., Hayashi, T., Oshima, Y., Tsuji, S., Tanaka, S. Hypoglossal nerve palsy as a cause of severe dysphasia along with the oropharyngeal stenosis due to occipito-cervical kyphosis. Case Reports in Orthopedics, vol. 2019, Article ID 7982847, 4 pages, 2019. doi:10.1155/2019/7982847

Uchigami, H., Sato, K., Kubota, A., Hayashi, T., Shimizu, J., Ikemura, M., Toda, T. ‘Localized’ chronic invasive fungal rhinosinusitis without serological abnormalities. Neurology and Clinical Neuroscience, 7(2):96-97, 2019. doi:10.1111/ncn3.12252

Miyano, R., Kurihara, M., Orimo, K., Mano, T., Kaburaki, T., Tanaka, R., Nishijima, H., Ikemura, M., Takahashi, M., Mori, H., Mutoh, T., Hamada, M., Hayashi, T., Toda, T. Severe visual impairment and subclinical encephalitis preceding clinical signs of chondritis in relapsing polychondritis. Neurology and Clinical Neuroscience, 7(2):75-77, 2019. doi:10.1111/ncn3.12243

Katsuse, K., Kurihara, M., Sugiyama, Y., Kodama, S., Takahashi, M., Momose, T., Yumoto, M., Kaneko, K., Takahashi, T., Kubota, A., Hayashi, T., Toda, T. Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease. Multiple Sclerosis and Related Disorders, 27:91-94, 2019. doi:10.1016/j.msard.2018.10.012

Murabe, N., Mori, T., Fukuda, S., Isoo, N., Ohno, T., Mizukami, H., Ozawa, K., Yoshimura, Y., Sakurai, M. Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal. Scientific Reports 8(1): 16536, 2018. doi:10.1038/s41598-018-34961-z

Niido, M., Fukuda, S., Ohno, T., Sakurai, M. Specific distribution of target muscles receiving transient cortico-motoneuronal direct connections in the juvenile rodent: similarity to higher primates. Teikyo medical journal 41(4):137-148, 2018.

Gondo, T., Kurihara, M., Sugiyama, Y., Mano, T., Mori, H., Hayashi T., Tsuji S. Longitudinally extensive vasogenic edema following spinal cord infarction. Neurology and Clinical Neuroscience, 6(5):143-145, 2018. doi.org/10.1111/ncn3.12215

Kodama, S., Mano, T., Kakumoto, T., Ishiura, H., Hagiwara, A., Kamiya, K., Hayashi, T., Tsuji, S. Ketotic hyperglycemia-related seizure with reversible white matter lesion: metabolic implication of its reversibility based on magnetic resonance spectroscopy study. Journal of the Neurological Sciences, 390:20-21, 2018. doi:10.1016/j.jns.2018.04.006

Ishiura, H., Doi, K., Mitsui, J., Yoshimura, J., Matsukawa, MK., Fujiyama, A, Toyoshima, Y., Kakita, A., Takahashi, H., Suzuki, Y., Sugano, S., Qu, W., Ichikawa, K., Yurino, H., Higasa, K., Shibata, S., Mitsue, A., Tanaka, M., Ichikawa, Y., Takahashi, Y., Date, H., Matsukawa, T., Kanda, J., Nakamoto, FK., Higashihara, M., Abe, K., Koike, R., Sasagawa, M., Kurohane, Y., Hasegawa, N., Kanesawa, N., Kondo, T., Tada, M., Takano, H., Saito, Y., Sanpei, K., Onodera, O., Nishizawa, M., Nakamura, M., Sakiyama, Y., Ohtsuka, M., Ueki, A., Kaida, K., Shimizu, J., Hanajima, R., Hayashi, T., Terao, Y., Terada, S., Hamada, M., Shirota, Y., Kubota, A., Ugawa, Y., Koh, K., Takiyama, Y., Ohsawa-Yoshida, N., Ishiura, S., Kira, J., Tamaoka, A., Akiyama, H., Otsuki, T., Sano, A., Ikeda, A., Goto, J., Morishita, S., Tsuji, S. Intronic TTTCA pentanucleotide repeat expansions cause benign adult familial myoclonic epilepsy. Nature Genetics, 50(4):581–590, 2018. doi:10.1038/s41588-018-0067-2 PMID:29507423

Kurihara, M., Ishiura, H., Sasaki T., Otsuka J., Hayashi T., Terao Y., Matsukawa T., Mitsui J., Kaneko J., Nishiyama K., Doi K., Yoshimura J., Morishita S., Shimizu J., Tsuji S. Novel de novo KCND3 mutation in a Japanese patient with intellectual disability, cerebellar ataxia, myoclonus, and dystonia. Cerebellum, 17(2):273-242, 2018. doi: 10.1007/s12311-017-0883-4 PMID:28895081

Kodama, S., Mano, T., Masuzawa, A., Hirata, Y., Nagasako, Y., Mano, KK., Hamada, M., Terao, Y., Hayashi, T., Ono, M., Tsuji, S. Tacrolimus-induced reversible cerebral vasoconstriction syndrome with delayed multi-segmental vasoconstriction. Journal of Stroke and Cerebrovascular Diseases 26(5):e75–e77, 2017. doi:10.1016/j.jstrokecerebrovasdis.2017.03.006 PMID:28342655

Yoshida, M., Hayashi, T., Fujii, K., Kawai, K., Tsuji, S., Iwata, A. Recovered recall memory after decompression of the fornix by surgical removal of pineal tumor. Neurology, 86(8):790-791, 2016. doi:10.1212/WNL.0000000000002394 PMID:26903489

Isoo, N., Ohno, T., Isowaki, M., Fukuda, S., Murabe, N., Mizukami, H., Ozawa, K., Mishina, M., Sakurai, M. The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period. Scientific Reports 6:34196, 2016. doi:10.1038/srep34196 PMID:27677249

Ogawa, G. Identification of auditory fields responding to synthetic vowels in rat auditory cortex. Teikyo medical journal 39(5):183-198,2016.

Ogawa, G, Nishida, Y., Fukuda, S., Kudoh, M. A rat model for human speech sound discrimination: Discrimination learning of synthetic vowels by rats. Teikyo medical journal 39(3):95-107, 2016.

Maeda, H., Fukuda, S., Kameda, H., Murabe, N., Isoo, N., Mizukami, H., Ozawa, K., Sakurai, M. Corticospinal axons make direct synaptic connections with spinal motoneurons innervating forearm muscles early during postnatal development in the rat. The Journal of Physiology, 594(1):189-205, 2016. doi:10.1113/JP270885 PMID: 26503304

Tanaka, N., Hayashi, T., Tsuji, S., Iwata, A. Abdominal tremor in Parkinson’s disease. Movement Disorders Clinical Practice, 2(1):104-105, 2015. DOI:10.1002/mdc3.12119.

Watanabe, T., Hanajima, R., Shirota, Y., Tsutsumi, R., Shimizu, T., Hayashi, T., Terao, Y., Ugawa, Y., Katsura, M., Kunimatsu, A., Ohtomo, K., Hirose, S., Miyashita, Y., Konishi, S. Effects of rTMS of Pre-Supplementary Motor Area on Fronto Basal Ganglia Network Activity during Stop-Signal Task. Journal of Neuroscience. 35(12):4813-4823, 2015. doi:10.1523/JNEUROSCI.3761-14.2015 PMID:25810512

Shinya, Y., Miyawaki, S., Nakatomi, H., Okano, A., Imai, H., Shin, M., Sato, K., Tsuchida, T., Hayashi, T., Terao, Y., Numakura, S.,j Morikawa, T., Shibahara, J., Kikuta, S., Kondo, K., Tatsuno, K., Mori, H., Kunimatsu, A., Tsuji, S., Saito, N. Recurrent cerebral aneurysm formation and rupture within a short period due to invasive aspergillosis of the nasal sinus; pathological analysis of the catastrophic clinical course. International Journal of Clinical and Experimental Pathology 8(10):13510-13522, 2015. PMID:26722566

Kamiyama, T., Kameda, H., Murabe, N., Fukuda, S., Yoshioka, N., Mizukami, H., Ozawa, K., Sakurai, M. Corticospinal tract development and spinal cord innervation differ between cervical and lumbar targets. Journal of Neuroscience 35:1181-1191, 2015. PMID:25609632

Ishiura, H., Takahashi, Y., Hayashi, T., Saito, K., Furuya, H., Watanabe, M., Murata, M., Suzuki, M., Sugiura, A., Umemura, H., Ueda, N., Goto, J., Tsuji, S. Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses. Journal of Human Genetics, 59(3):163-72, 2014. DOI:10.1038/jhg.2013.139 PMID:24451228

書籍

大森治紀ら（監修）林俊宏（分担執筆）　標準生理学第10版、医学書院、東京、2025．

林俊宏、高橋倫子（監訳）．コスタンゾ明解生理学　原書第7版．エルゼビア・ジャパン，東京　2023．

林 俊宏、高橋 倫子(監訳)．コスタンゾ明解生理学 原著第6版．エルゼビア・ジャパン，東京 2019． (ISBN: 4860342364)

最近の学会発表

落合里浮，吉田崇将，林俊宏， “大脳皮質における臨界フリッカー融合知覚の神経相関”， “Neural correlates of critical flicker fusion in the rodent cerebral cortex”，2LBA-009，APPW2025 （第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会 合同大会），千葉県千葉市・幕張メッセ（国際会議場・国際展示場），2025年3月. （ポスター発表）

高木宏徳, 磯尾紀子, 吉田崇将, 磯尾直之, 堀由起子, 富田泰輔, 林俊宏．Establishment of uptake assay for tau-containing extracellular vesicles into cells [★1P-138] APPW2025 （第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会 合同大会），千葉県千葉市・幕張メッセ（国際会議場・国際展示場），2025年3月. （ポスター発表）

濵田虎之介, 大野孝恵, 福田諭, 村部直之, 宮下俊雄, 林俊宏. The red nucleus and its new classification. 2P-032 APPW2025 （第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会 合同大会），千葉県千葉市・幕張メッセ（国際会議場・国際展示場），2025年3月. （ポスター発表）

落合里浮, 吉田崇将, 林俊宏, “マウスを用いたフリッカー知覚の大脳皮質回路メカニズムの解明”, 若手演題1-2, 第254回生理学東京談話会, 東京都文京区・東京科学大学 湯島キャンパス, 2024年11月. （口頭発表）

Takae Ohno, Hideo Miyake, Satoshi Fukuda, Naoyuki Murabe, Toshio Mitashita, Toshihiro Hayashi. “The red nucleus and its networks”. 北米神経科学学会2024（Neuroscience 2024）Chicago, October 5-9, 2024

Satoshi Fukuda, Masaki Sakurai. “Corticomotoneuronal direct synapses and their regression during development in rodents”, PSTR230.02/I16, 北米神経科学学会2024（Neuroscience 2024）, Chicago, October 7, 2024

澤重太洋，池末幾講，磯尾紀子，高木宏徳，吉田崇将，磯尾直之，堀由起子，富田泰輔，林俊宏，“タウ内包細胞外小胞のマウス脳内における細胞間伝播”，“Cell-to-cell transmission of tau-containing extracellular vesicles in the mouse brain”，2P-315，NEURO2024（第47回日本神経科学大会），福岡県福岡市・福岡コンベンションセンター，2024年7月．（ポスター発表）

川田賢太郎，磯尾紀子，高木宏徳，吉田崇将，磯尾直之，堀由起子，富田泰輔，林俊宏，“テトラスパニン発現量の少ないタウ内包細胞外小胞の同定”，“Identification of low-tetraspanin extracellular vesicles containing tau”，1TS13m-01，NEURO2024（第47回日本神経科学大会），福岡県福岡市・福岡コンベンションセンター，2024年7月．（口頭発表）

村部直之，桜井正樹，” 発達期に運動ニューロンと一過性結合するマウス皮質脊髄細胞の成体での投射パターン“，” Adult projection pattern of the corticospinal neurons with transient motoneuronal connections during development in mice”，2P-415， NEURO2024（第47回日本神経科学大会），福岡県福岡市・福岡コンベンションセンター，2024年7月．（ポスター発表）

福田 諭, 桜井 正樹, “齧歯類発達期における皮質-運動ニューロン間直接シナプスとその退行：形態学的・電気生理学的解析”, “Corticomotoneuronal direct synapses and their regression during development in rodents: Morphological and electrophysiological analysis”, 3P-411, NEURO2024（第47回日本神経科学大会），福岡県福岡市・福岡コンベンションセンター，2024年7月．（ポスター発表）

吉田 崇将, 黒木 暁, 佐野 千枝, 安藤 れい子, 仲柴 俊昭, 糸原 重美, 田中 尚樹, 林 俊宏．統合失調症モデルマウスにおける大脳皮質機能的ネットワークの変容．第101回日本生理学会大会，北九州，2024年3月29日．

中島 一夫, 加藤 忠史．気分障害を伴う遺伝性疾患の遺伝子改変モデルマウスの研究．第101回日本生理学会大会（シンポジウム），北九州，2024年3月29日．

三宅英雄、福田諭、村部直之、林俊宏、大野孝恵．赤核とそのネットワーク：逆行性ベクターを用いた標的細胞への選択的アプローチ．第253回生理学東京談話会｜日本生理学会，東京，2023年12月9日．

T. Ohno, H. Miyake, N. Murabe, S. Fukuda, S. Takai, T. Yoshida, K. Nakajima, T. Hayashi. The red nucleus and its circuit network: cell identification through a target-selective approach utilizing retrograde vectors. Neuroscinece 2023, Washington, D.C., Nov. 11– 15.

Isoo, N., Kawata, K., Takagi, H., Iso-o, N., Hori, Y., Tomita, T., Hayashi, T. Characterization of tau-containing exosomes derived from Neuro2a cells. Neuroscinece 2023, Washington, D.C., Nov. 11– 15.

H. Sato, K. Kasuga, N. Isoo, T. Hayashi, T. Ikeuchi, H. Yukiko, T. Tomita. Screening for the regulators of tau secretion. Neuroscinece 2023, Washington, D.C., Nov. 11– 15.

Satoshi Fukuda, Masaki Sakurai. Electrophysiological analysis of temporal course of transient corticomotoneuronal connections during development in rodents. The 46th Annual Meeting of the Japan Neuroscience Society, Sendai, Japan, Aug 3, 2023.

Takae Ohno, Satoshi Fukuda, Naoyuki Murabe, Hideo Miyake, Shu Takai, Toshihiro Hayashi. The 46th Annual Meeting of the Japan Neuroscience Society, Sendai, Japan, Aug 2, 2023.

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